business development

Strategic partnerships are an integral part of our model. We value collaboration with companies and institutions at the forefront of scientific innovation and we are focused on building robust relationships and alliances in the service of helping patients in need.

We seek academic and industry partners, both within the U.S. and globally, committed to making life-changing medicines as rapidly and safely as possible. Additionally, we are open to discussing portfolio divestments and licensing of pharmaceutical assets that are no longer being actively developed.

Patidegib topical gel

Topical HH Inhibitor (Patidegib) for Gorlin Syndrome


Gorlin syndrome, Frequent basal cell carcinoma

genetic source

PTCH1 (patched-1, a smoothened inhibitor)

patients (us + eu)



topical small molecule

Program summary

Patidegib topical gel is designed to selectively replace and/or augment the function of Patched (Ptc), a naturally occurring hedgehog signaling pathway inhibitor, by blocking the Smoothened (Smo) protein. Acting as a tumor suppressor, patidegib is designed to allow cells to function normally and limit the overproduction of tumors found in patients with Gorlin Syndrome and High Frequency Basal Cell Carcinoma. Because oral formulations for this treatment typically have serious systemic side effects which cause many patients to discontinue treatment, patidegib is formulated as a topical gel to reduce its side effect profile due to its minimal systemic exposure. BridgeBio is currently investigating the safety and efficacy of patidegib in patients with Gorlin Syndrome in a Phase 3 clinical trial.