Sr. IT Infrastructure Engineer

BridgeBio San Francisco, CA/Hybrid IT

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About BridgeBio

BridgeBio is a biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company has built a portfolio of 20+ drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs.

Our focus on scientific excellence and rapid execution aim to translate today’s discoveries into tomorrow’s medicines. We have U.S. offices in San Francisco, Palo Alto, and Raleigh, with small satellites in other parts of the country. We also have international offices in Montreal, Canada, and Zurich, Switzerland, and are expanding across Europe.

To learn more about our story and company culture, visit us at

Who You Are

We are looking for a Senior IT Infrastructure Engineer to manage and maintain the implementation, upgrade, operations, and compliance of IT Infrastructure Systems. This role will report directly to the Director, IT Server, Storage, and Cloud. The Senior IT Infrastructure Engineer is responsible for the overall technical architecture, design, installation/configuration, operation, and maintenance of systems hardware, software, and network-related infrastructure. This individual is a thought leader, process-focused, detail-oriented, organized, strategic, and thorough in ensuring IT is the best to support the business and enable continuing innovation within the infrastructure system. This role collaborates closely with business stakeholders and Business IT to ensure that the overall BridgeBio business computing infrastructure enables business goals.


  • Primary process owner for multi-tiered IT infrastructure services composed of multiple vendor and internal parties
  • Manage networks, servers, and core infrastructure services (AWS, Azure, Meraki Networks, DNS, Email Protection, Okta, Data Protection)
  • Ability to script with Powershell
  • Manage and support server and infra technologies both on-prem and cloud (Azure & AWS)
  • Proficient with AWS services (EC2, IAM, S3, Workspaces)
  • Administer Office 365 for user account and mailbox management, calendar processing, shared mailbox, distribution list management, and licensing
  • Escalation support for all user account-related tasks consisting of AD/Email, video conferencing, and mobile devices
  • Oversee and support IT Infrastructure Managed Service Provider
  • Manage internet service providers across all Sites
  • Share management of core Business platforms (Office 365, Zoom, SharePoint, Printers, OneDrive, Egnyte, etc.)
  • Support conferencing technology such as Zoom, Zoom Rooms, and Teams
  • Develop and improve the Infrastructure Service in the areas of monitoring, provisioning, and request processes
  • Manage security incidents, investigations, resolutions, and reporting
  • Drive resolution of high-severity outages impacting IT infrastructure
  • Responsible for budget commitments, forecasting, and tracking for the group as related to technology services within the service area
  • Contribute to the development of the IT vision; translate the vision into short-/long- term goals and deliverables that support the operations of IT infrastructure
  • Manage the engagement, delivery, and oversight of activities related to Infrastructure services provided by external vendors and service providers
  • Lead the evaluation and selection of systems and infrastructure solutions in conjunction with IT strategy and business requirements
  • Partner with the business areas to identify system requirements and translate business requirements into functional service projects, enhancements, and support
  • Conduct design review of systems and applications to ensure adherence with identified stability, performance, and security standards
  • Support GxP systems and SOX compliance activities

No matter your role at BridgeBio, successful team members are:

  • Patient Champions, who put patients first and uphold strict ethical standards
  • Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset
  • Truth Seekers, who are detailed, rational, and humble problem solvers
  • Individuals Who Inspire Excellence in themselves and those around them
  • High-quality executors, who execute against goals and milestones with quality, precision, and speed

Education, Experience & Skills Requirements

  • 5+ years of experience in IT, providing supervisory and direct technical support for IT Infrastructure
  • 3+ years of IT experience in similarly sized growing Biotech companies
  • Broad IT Infrastructure experience, with emphasis on Life Sciences-related systems delivery, required
  • Proven experience with managing and utilizing cloud infrastructure in a service delivery process
  • Successful experience managing the following infrastructure: Meraki FW/Wi-Fi, Azure, AWS EC2, InfoSec Monitoring Services, MS Active Directory, DNS, Okta, Server Backups, NAS Storage Solutions
  • Knowledge or experience with the following infrastructure processes: DR and HA, Change Control, Maintenance management, InfoSec Breach Management
  • Knowledge of applicable regulatory requirements, data privacy practices, and laws, including FDA 21 CFR Part 11, SOX, and HIPAA, as they relate to the management of IT Infrastructure
  • Must have a strong understanding of IT Infrastructure as part of a business function (SLAs, ITIL practices, etc.)
  • Experience with Computer Systems Validation (CSV) and good documentation practices is highly desired
  • Possess solid project management skills, can set and manage expectations extremely well, work effectively with others, and are exceedingly productive on your own while producing quality results
  • Must be able to handle changing and competing priorities where the path forward is not always clear at the outset and use good judgment in stressful situations
  • Must communicate well, both in writing and verbally, including success in communicating ideas in both technical and user-friendly language and technical writing skills
  • Results-oriented team player who leads by example and takes full accountability
  • A passion for business transformation, the ability to lead change inclusively, and the desire to bring the best combination of skills together in a team
  • Ability to operate in a cross-functional / matrix environment
  • High level of personal integrity consistent with BridgeBío’s values

What We Offer

  • Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
  • A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
  • An unyielding commitment to always putting patients first. Learn more about how we do this here
  • A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science
  • A place where you own the vision – both for your program and your own career path
  • A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
  • Access to learning and development resources to help you get in the best professional shape of your life
  • Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
  • Flexible PTO
  • Rapid career advancement for strong performers
  • Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time 
  • Partnerships with leading institutions
  • Commitment to Diversity, Equity & Inclusion
At BridgeBio, we strive to provide a market-competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health benefits. Below is the anticipated salary range for candidates for this role who will work in California. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, educational background, location of residence and performance during the interview process. BridgeBio is a multi-state employer, and this salary range may not reflect positions based in other states.
$140,000$195,000 USD


Sr. IT Infrastructure Engineer

BridgeBio San Francisco, CA/Hybrid IT

Apply Now