Scientist I


Eidos Therapeutics

Role Title:

Scientist I




Eidos Therapeutics is developing a novel treatment for transthyretin (TTR) amyloidosis (ATTR), a progressive, fatal disease affecting multiple organs including the heart and peripheral nerves. Current treatment options focus on managing the symptoms of the conditions, but do not address the underlying cause of the disease: TTR tetramers destabilized by mutations or age. Eidos’ lead compound, AG10, is a small molecule that binds and stabilizes TTR in the blood, preventing the formation of amyloid and potentially halting progression of the disease. Launched in 2016 after years of research supported by Stanford’s TRAM and SPARK programs, Eidos is led by a team of veteran biotechnology executives. Together with patients and physicians, the company aims to provide a safe, effective treatment for ATTR as quickly as possible.

Position Summary:

The Scientist I is responsible for developing and conducting experiments to support Eidos’ clinical development program for AG10, a small molecule therapeutic for transthyretin amyloidosis. As a core member of the company’s research and development team, the scientist will work directly with senior leadership members including our Chief Scientific Officer and Founder.

Essential Skills & Functions:

  • Conduct established experimental protocols (serum based fluorescence assays,immunoblotting) to measure binding of target protein by by small molecules,
  • Develop and implement novel assays (e.g., plasma and serum plate assays) to measure transthyretin amyloid fibril formation
  • Collect and present data to broader Eidos team including scientific, clinical, and business leaders
  • Understand overall scientific objectives of Eidos and independently design and pursue experimental directions to support company objectives
  • Build effective working relationships throughout the organization to achieve goals
  • Maintain knowledge of state-of-the-art principles and theories and possess advanced knowledge of scientific principles and concepts in field of expertise
  • Proactively contribute to and demonstrate scientific leadership in scientific literature, Intellectual Property, manuscripts for publication, regulatory submissions, conferences, and seminars

Preferred Education and Experience:

  • BA/BS in biological field required, PhD preferred
  • Laboratory experience in techinques of protein chemistry is required. Expertise in enzyme assays, protein characterization, and cell biology is preferred
  • Broad scientific skillset and record, as evidenced by familiarity with range of experimental procedures and strong publication record
  • Clear scientific curiosity and interest in drug development
  • Strong verbal and written communication skills
  • Prior experience working in a start-up environment is a plus
  • Passion for helping patients


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