Pan-KRAS inhibitor

Pan-KRAS inhibitor for KRAS cancers

estimated prevalence

>500,000

Disease

KRAS+ cancers

Genetic Source

KRAS

Clinical Phase

Pre-clinical

Modality

molecule icon small molecule

BridgeBio’s pan-KRAS program targets KRASG12D and KRASG12V mutations present in a large percentage of colorectal, pancreatic and non-small cell lung cancer tumors. BridgeBio has achieved in vivo target engagement and has identified leads with promising oral bioavailability. Development candidate selection is planned for 2023.

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