Senior Scientist

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BridgeBio finds, develops, and delivers breakthrough medicines for genetic diseases. The company bridges remarkable advancements in genetic science with the entrepreneurial engine required to rapidly create lifesaving medicines for patients with unmet needs. Founded in 2015 by a team of industry veterans, the company has built a portfolio of 20 transformative drugs ranging from pre-clinical to late-stage development in multiple therapeutic areas including genetic dermatology, oncology, cardiology, neurology, endocrinology, renal disease, and ophthalmology. The company’s focus on scientific excellence and rapid execution aims to translate today’s discoveries into tomorrow’s medicines. We have offices in San Francisco, Palo Alto, Boston, New York, and Raleigh, with small satellites in other parts of the country.

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South San Francisco

Who You Are

This is an exciting opportunity for a highly motivated scientist to join the BridgeBio Oncology Therapeutics (BBOT) group in South San Francisco. This successful candidate will join a group of investigators developing novel small molecule cancer therapeutics. This individual will lead a variety of molecular and cellular biology and biochemistry experiments to empower the optimization and progression of our lead oncology research programs. We are looking for a talented and enthusiastic individual who thrives in a collaborative, fast-paced, and growing environment.


  • Design, perform and oversee the evaluation of molecular targets, therapeutic concepts, and agents
  • Define critical path studies needed to support hypothesis-based research
  • Analyze, interpret and present complex data, formulate conclusions, and propose experimental strategies within the context of broader project goals
  • Maintain knowledge of scientific advances and competitive activity from literature, scientific meetings, and external contacts
  • Supervise, train and develop junior scientists
  • Work closely with medicinal chemists, PKDM scientists, and pharmacologists in a team matrix environment

Education, Experience & Skills Requirements

  • Doctorate degree (PhD), post-doctoral training, and ≥ 4 years of experience in oncology drug development, including cancer cell biology, molecular biology, biochemistry, and genomics
  • Those with experience in development candidate selection are especially encouraged to apply
  • Experience in cell signaling pathways, i.e. RTK, PI3K, and MAPK pathways highly desirable
  • Must be able to work in an innovative, fast-paced, and team-oriented environment
  • Strong written and oral communication skills

What We Offer

  • Patient Days, where we are fortunate enough to learn more about the lives we are looking to impact and a real exchange of ideas as to how we can improve our efforts
  • A culture inspired by our values: put patients first; think independently, be radically transparent; every minute counts, and let the science speak
  • Learning and development training to help employees be the best version of themselves
  • Collaborative business environment
  • Excellent compensation package (Base, Performance Bonus, Stock, RSU programs)
  • Excellent benefits package
  • Flexible PTO
  • With office locations in San Francisco, Boston, New York, and Raleigh, there are ample cross-collaboration opportunities with other BridgeBio Pharma programs
  • A fast-paced, data-driven, work environment with world-class R&D minds and capabilities
  • Work with the most productive groups of R&D operators in the industry
  • Partnerships with leading institutions
  • A platform for meaningful scientific contributions to shine
  • Commitment to Diversity & Inclusion – with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels respected for who they are, empowered to contribute, inspired to lead, and supported in their efforts to do so

Senior Scientist

Apply Now