BridgeBio finds, develops, and delivers breakthrough medicines for genetic diseases. The company bridges remarkable advancements in genetic science with the entrepreneurial engine required to rapidly create lifesaving medicines for patients with unmet needs. Founded in 2015 by a team of industry veterans, the company has built a portfolio of 20 transformative drugs ranging from pre-clinical to late-stage development in multiple therapeutic areas, including genetic dermatology, oncology, cardiology, neurology, endocrinology, renal disease, and ophthalmology. The company’s focus on scientific excellence and rapid execution aim to translate today’s discoveries into tomorrow’s medicines. We have offices in San Francisco, Palo Alto, Boston, New York, and Raleigh with small satellites in other parts of the country.
To learn more, visit us at https://bridgebio.com
South San Francisco, CA
who you are
This is an exciting opportunity for a highly motivated Senior Research Associate to contribute to and support core drug discovery activities for the development of novel small molecule cancer therapeutics targeting Ras. The successful candidate will collaborate with members of our cancer biology team to conduct a variety of biochemistry, molecular and cellular biology experiments to enable the optimization and selection of therapeutics for our lead oncology research programs. This position includes some lab management and operational tasks. We are looking for a talented and enthusiastic individual who thrives in a collaborative, fast-paced, and growing environment to join our team.
- Execute pharmacology experiments (biochemical and cell-based assays) to assess the inhibition or activation of cell signaling targets in the oncology setting
- Engineer cell lines to overexpress/knockdown targets of interest
- Conduct high throughput compound screens to identify combination therapies
- Independently plan and design experiments using mostly (but not limited to) small molecule therapeutics
- Interpret and communicate experimental data in collaboration with supervisor
- Keep records in written and electronic laboratory notebooks
education, experience & skills requirements
- BS/MS in a biology-related discipline
- BS and 4 years, or MS and 3 years of hands-on experience in a cell/molecular biology laboratory. Oncology setting required.
- Experience in cell signaling and feedback mechanisms, preferably in PI3K/ERK pathway modulation.
- Experience with mammalian cell culture (cancer cell lines), cell line engineering (shRNA, CRISPR/Cas9), RT-PCR, western blot/immunoprecipitation protein expression quantification (ELISA, MSD, FACS), and high content imaging
- Must be able to work in an innovative, fast-paced, and team-oriented environment
- Strong written and oral communication skills
what we offer
- Patient Days, where we are fortunate enough to learn more about the lives we are looking to impact and a real exchange of ideas as to how we can improve our efforts
- A culture inspired by our values: put patients first; think independently, be radically transparent; every minute counts, and let the science speak
- Learning and development training to help employees be the best version of themselves
- Collaborative business environment
- Excellent compensation package (Base, Performance Bonus, Stock, RSU programs)
- Excellent benefits package
- Flexible PTO
- With office locations in San Francisco, Boston, New York, and Raleigh, there are ample cross-collaboration opportunities with other BridgeBio Pharma programs
- A fast-paced, data-driven, work environment with world-class R&D minds and capabilities
- Work with the most productive groups of R&D operators in the industry
- Partnerships with leading institutions
- A platform for meaningful scientific contributions to shine
- Commitment to Diversity & Inclusion – with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels respected for who they are, empowered to contribute, inspired to lead, and supported in their efforts to do so