Lead/Principal Scientist, Renal Biology

BridgeBioX Palo Alto, California, United States Preclinical

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About BridgeBioX and BridgeBio Pharma

Leveraging extensive inherited disease experience and an established drug development infrastructure, BridgeBio recently formed a discovery research group called BridgeBioX. The vision of BridgeBioX is to use cutting-edge biology to develop breakthrough medicines in genetic diseases with high unmet needs across multiple therapeutic areas including oncology, neurology, pulmonology, and cardiology. BridgeBioX is building out lab space on the Stanford Life Sciences campus to create a hybrid industry-academic environment where scientists from the top labs around the world can collaborate with senior BridgeBio leadership and advisors.

BridgeBio is a biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company has built a portfolio of 30+ drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs.

Our focus on scientific excellence and rapid execution aims to translate today’s discoveries into tomorrow’s medicines. We have U.S. offices in San Francisco, Palo Alto, Boston, New York, and Raleigh, with small satellites in other parts of the country. We also have international offices in Montreal, Canada, and Zug, Switzerland, and are expanding across Europe.

To learn more about our story and company culture, visit us at https://bridgebio.com

Who You Are

We are seeking a highly motivated scientist to lead discovery biology and bring our research programs in renal diseases from early hits into clinic. The ideal candidate brings expertise in renal biology and the development of functional assays. A background in industrial drug discovery and experience with renal diseases or physiology is preferred. Successful candidates will be able to thrive in a fast-paced, action-oriented team environment and display a clear passion for science and impact. The individual will have demonstrated evidence of technical expertise and experience overcoming challenges and moving projects forward with urgency.  Experience in guiding junior scientists and working with CROs is preferred. They will be interested in contributing at the bench and be dedicated to the scientific development of themselves and their team.


  • Responsible for the design, planning, and execution of small molecule discovery projects in genetic renal diseases
  • Develop functional assays to enable SAR, MoA studies, target engagement measurement, and pathway modulation
  • Manage outsourced cell biology and, later, in vivo biology resources, establishing and maintaining excellent working relationships with CROs and academic collaborators
  • Work collaboratively in cross-functional teams, including chemistry, operations, clinical, etc.
  • Communicate findings and implications to the internal team and senior leadership
  • Help formulate overall preclinical strategy and drive basic research toward the clinic 

No matter your role at BridgeBio, successful team members are:

  • Patient Champions, who put patients first and uphold strict ethical standards
  • Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset
  • Truth Seekers, who are detailed, rational, and humble problem solvers
  • Individuals Who Inspire Excellence in themselves and those around them
  • High-quality executors, who execute against goals and milestones with quality, precision, and speed

Education, Experience & Skills Requirements

  • Ph.D. or equivalent in molecular biology, cellular biology, biochemistry, genetics, or related fields; a strong publication record is a plus
  • More than 3 years of industrial drug discovery experience, with a track record of pre-clinical discovery and development of small molecule drugs
  • Sound knowledge of disciplines involved in drug discovery (cell-based disease models, target engagement and target modulation assays, cell viability assays, biomarker discovery, PD/PK, and efficacy studies)
  • Therapeutic domain expertise in renal diseases
  • Strong intellectual curiosity as demonstrated by routine engagement with the scientific community and familiarity with literature
  • Demonstrated ability to work within highly skilled teams in a fast-paced, quickly evolving technical environment

What We Offer

  • Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
  • A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
  • An unyielding commitment to always putting patients first. Learn more about how we do this here
  • A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science
  • A place where you own the vision – both for your program and your own career path
  • A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
  • Access to learning and development resources to help you get in the best professional shape of your life
  • Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
  • Flexible PTO
  • Rapid career advancement for strong performers
  • Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time 
  • Partnerships with leading institutions
  • Commitment to Diversity, Equity & Inclusion
At BridgeBio, we strive to provide a market-competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health benefits. Below is the anticipated salary range for candidates for this role who will work in California. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, educational background, location of residence and performance during the interview process. BridgeBio is a multi-state employer, and this salary range may not reflect positions based in other states.
$130,000$215,000 USD


Lead/Principal Scientist, Renal Biology

BridgeBioX Palo Alto, California, United States Preclinical

Apply Now