Principal Statistical Programmer

Full-TimeBridgeBioSan Francisco, CABiostatistics & Data Management

Apply Now

About BridgeBio

BridgeBio is a biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company has built a portfolio of 30+ drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs.

Our focus on scientific excellence and rapid execution aim to translate today’s discoveries into tomorrow’s medicines. We have U.S. offices in San Francisco, Palo Alto, Boston, New York, and Raleigh, with small satellites in other parts of the country. We also have international offices in Montreal, Canada, and Zug, Switzerland, and are expanding across Europe.

To learn more about our story and company culture, visit us at https://bridgebio.com

Who You Are:

The Principal Statistical Programmer is a member of the Biostatistics team and is responsible for performing all SAS programming tasks required for clinical trial analysis and reporting. This position works closely with other members of the Biostatistics and Data Management departments on various clinical projects. The Principal Statistical Programmer functions as Lead Statistical Programmer on multiple projects. The successful candidate will interact with internal and contract research organization (CRO) programmers in preparing analysis programs.
Responsibilities:
  • Lead programming efforts on all clinical trials conducted by ML Bio
  • Collaborate cross-functionally (clinical, data management, statistician, regulatory, medical, etc.)
  • Participates in developing Standard Operating Procedures (SOPs), policies, and guidelines
  • Remain informed of new developments in programming that are relevant to the industry and contribute to the innovation of new reporting systems
  • Establish and implement programming standards that comply with regulatory requirements; ensure that the datasets are in CDISC format and submission-ready
  • Develop standard macros and/or tools in SAS for data analysis and reporting
  • QC all the deliverables before transferring them to either internal or external clients
  • Oversee the statistical programming work of CROs by establishing regular interactions and setting an expectation on deliverables and timelines
  • Develop the SAS programs for IB, DSUR update, periodic safety update, and other ad hoc safety analyses
  • Create or validate SDTM/ADaM data sets and TFL outputs to ensure accuracy and consistency
  • Prepare or validate submission package, e.g., define.xml, Pinnacle 21 report, reviewer guide, etc.
  • Generate ad-hoc datasets and TFLs as needed

  • No matter your role at BridgeBio, successful team members are:
  • Patient Champions, who put patients first and uphold strict ethical standards
  • Entrepreneurial Operators, who drive towards practical solutions and have an ownership mindset
  • Truth Seekers, who are detailed, rational, and humble problem solvers
  • Individuals Who Inspire Excellence in themselves and those around them
  • High-quality executors, who execute against goals and milestones with quality, precision, and speed
Education, Experience & Skills Requirements:
  • Bachelor’s/Master’s degree in a scientific discipline; prefer 5+ years of experience for M.S., and 8+ years of experience for B.S in Biotech, Pharmaceutical, or CRO
  • Proficiency in SAS language, procedures, and functions including SAS Macro, Base SAS, SAS/STAT, and SAS/GRAPH
  • Experience leading SAS programming projects in the pharmaceutical industry demonstrated by the ability to independently act as the point of contact on the statistical programming for all phases of clinical trials
  • Proficient in industry standards and clinical trial methodologies
  • Familiar with CDISC standards, e.g., SDTM, ADaM, TAUG, submission, etc.
  • Possess project management skills within the Statistical Programming function.
  • Good communication and organizational skills
What We Offer:
  • Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
  • A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
  • An unyielding commitment to always putting patients first. Learn more about how we do this here
  • A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science
  • A place where you own the vision – both for your program and your own career path
  • A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
  • Access to learning and development resources to help you get in the best professional shape of your life
  • Robust and market competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
  • Flexible PTO
  • Rapid career advancement for strong performers
  • Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time
  • Partnerships with leading institutions
  • Commitment to Diversity, Equity & Inclusion – with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels seen, valued, and heard
We will not accept unsolicited resumes from agencies. Please do not send agency resumes to our website or BridgeBio and affiliating employees.
careers

Principal Statistical Programmer

Full-TimeBridgeBioSan Francisco, CABiostatistics & Data Management

Apply Now