BridgeBio ultimately exists to help patients. Millions worldwide are afflicted with genetic diseases, but small patient populations and industry reluctance to conduct early-stage development means that for many, treatments have not been forthcoming. We are committed to bridging this gap: between business case and scientific possibility, between patient and hope.
To learn more, visit us at: https://bridgebio.com
San Francisco, CA
Who you are
We are seeking a highly motivated biomarker scientist to support the discovery and development of biomarkers for therapeutic programs across the BridgeBio subsidiaries of Mendelian genetic diseases and genetically-defined cancers.
The biomarker scientist will work with scientists within BridgeBio as well as contract research organizations to identify, design, implement, and validate candidate biomarker assays for multiple disorders relevant to BridgeBio’s subsidiary companies. The ideal candidate will have a proven track record of experimental science as well as project and vendor management for the development of biomarker assays and/or companion diagnostics. This position reports to the CSO and will work with all functional areas.
Key skills for this role include reading and understanding published biomarker approaches, rapidly learning new therapeutic and disease areas, interface and collaborate with internal scientists, CRO teams, and cross-functional teams who are experts on a particular disease program. Hands-on experience managing technical teams and collaborating with a variety of cross-functional stakeholders is key.
- Lead the development of biomarker, target engagement assays to support research and development decisions and clinical trials
- Work independently and collaboratively with scientists at BridgeBio subsidiaries, consultants, and CROs in support of biomarker development, assessment, qualification, and validation
- Rotate focus among multiple BridgeBio subsidiaries over time to provide biomarker expertise, strategy, and support
- Draft biomarker or surrogate endpoint sections of regulatory submissions
Education, Experience & Skills Requirements
- Ph.D., MD/Ph.D. or equivalent experience in pharmacology, biochemistry, or related discipline – post-doc preferred
- 10+ years of industry experience in assay and biomarker development
- Experience developing and implementing biomarker assays using various modalities (qPCR, ELISA, IHC, Western blot, flow cytometry)
- Experience drafting regulatory submission documents
- Strong CRO management capabilities
- Ability to work in a small company with a largely virtual environment.
- Ability to manage complexity and uncertainty
- Strong team interaction and communication skills
- Embraces the BridgeBio core values: 1. put patients first; 2. think independently, 3. be radically transparent; 4. every minute counts; 5. let the science speak
What We Offer
- Patient Days, where we are fortunate enough to learn more about the lives we are looking to impact and a real exchange of ideas as to how we can improve our efforts
- A culture inspired by our values: put patients first; think independently, be radically transparent; every minute counts, and let the science speak
- Learning and development training to help employees be the best version of themselves
- Collaborative business environment
- Excellent compensation package (Base, Performance Bonus, Stock, RSU programs)
- Excellent benefits package
- Flexible PTO
- With office locations in San Francisco, Boston, New York, and Raleigh, there are ample cross-collaboration opportunities with other BridgeBio Pharma programs
- A fast-paced, data-driven, work environment with world-class R&D minds and capabilities
- Work with the most productive groups of R&D operators in the industry
- Partnerships with leading institutions
- A platform for meaningful scientific contributions to shine
- Commitment to Diversity & Inclusion – with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels respected for who they are, empowered to contribute, inspired to lead, and supported in their efforts to do so