Director, Program Management

Calcilytix San Francisco, CA/Hybrid Program Management

Apply Now

About Calcilytix & BridgeBio Pharma

Calcilytix Therapeutics, an affiliate of BridgeBio Pharma, is developing encaleret (CLTX-305), a negative allosteric modulator of the calcium-sensing receptor (CaSR) for the treatment of Autosomal Dominant Hypocalcemia Type 1 (ADH1), a genetic cause of hypoparathyroidism. Encaleret is currently being evaluated in a Phase 3 clinical study and has received Orphan Drug and Fast Track Designations from the US FDA.

BridgeBio is a biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company has built a portfolio of 30+ drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs.

Our focus on scientific excellence and rapid execution aims to translate today’s discoveries into tomorrow’s medicines. We have U.S. offices in San Francisco, Palo Alto, and Raleigh, with small satellites in other parts of the country. We also have international offices in Montreal, Canada, and Zurich, Switzerland, and are expanding across Europe.

To learn more about our story and company culture, visit us at |

Who You Are

This position will provide professional Program management leadership to one or more of BBIO’s clinical-stage programs. This position will report to the Vice President of Program Management and will be responsible for developing, organizing, managing, and driving development and portfolio strategies, plans, and deliverables for drug candidate(s) by collaborating with cross-functional team members to develop and execute integrated product development plans
This position will also support integrating the program management process improvements across BBIO to establish best practices for continued organizational growth. 


  • Oversee all program management activities, including planning, decision making, metrics reporting, and global risk management related to the cardiorenal Programs with a focus on the Encaleret program
  • Effectively manage team meetings, including the Program Core Team (PCT), by ensuring that objectives are clearly defined, capturing and disseminating meeting outcomes, information, and action items, and following up on critical actions with teams
  • Oversee ongoing development and maintenance of integrated cross-functional Program plans, including Target Product Profiles, to enable accurate financial and portfolio analysis and planning
  • Foster leadership, strategic thinking, and business acumen while setting high standards that drive alignment, collaboration, accountability, and goal achievement within Program teams
  • Identify and champion best practices in BBS Program Management, including the use of dashboards, templates, tools, and processes to drive efficiency, alignment, and effective planning
  • Reporting and presentation of program information to the Executive Team, functional heads, and other key stakeholders
  • Contribute to long-range planning (LRP) and budgetary planning at the program level
  • Facilitate decision-making, collaboration, and problem-solving with people at all levels of the organization to accomplish shared program goals
  • Clearly and proactively anticipate, identify, track, communicate, and propose resolution options for discrepancies in priorities and plans, prioritize complex  and multiple/conflicting responsibilities and/or issues
  • Effectively manage multiple Programs and responsibilities concurrently
  • Committed to maintaining a work environment that supports BBIO’s core values
  • Other duties as assigned

No matter your role at BridgeBio, successful team members are:

  • Patient Champions, who put patients first and uphold strict ethical standards
  • Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset
  • Truth Seekers, who are detailed, rational, and humble problem solvers
  • Individuals Who Inspire Excellence in themselves and those around them
  • High-quality executors, who execute against goals and milestones with quality, precision, and speed

Education, Experience & Skills Requirements

  • Bachelor’s degree or equivalent required (scientific or healthcare discipline preferred). Advanced degree preferred 
  • Minimum ten years of pharmaceutical, biotech industry programs, or program management experience with a strong knowledge of cross-functional drug development, including global regulatory authority guidelines 
  • Rare disease experience preferred
  • Ability to lead and manage a matrixed Program team and coordinate cross-functional aspects of drug development (e.g., preclinical, CMC, regulatory, clinical, quality, commercial, etc.) to achieve development milestones 
  • Established ability to create a comprehensive Program plan and prioritize the execution of complex tasks within a team environment
  • Ability to influence teams to meet or exceed Program deadlines consistently
  • Experience in leading and managing team meetings; proven ability to create opportunities for meeting efficiency
  • Demonstrated team management and team-building skills; enthusiastic about creating a thriving environment for teamwork, collaboration, and cooperation
  • Effective communicator who can develop strong relationships to facilitate Program operations outside the context of formal meetings; able to effectively communicate with supervisor, co-workers, and external partners daily, in-person, by phone, and by email
  • Proactive problem solver with detailed organizational skills 
  • Has expert skills with the Microsoft Office Suite: Excel, Program, PowerPoint, Word, and Outlook; ability to create compelling presentations for internal and external use
  • Up to 10-20%, travel may be required 

What We Offer

  • Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
  • A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
  • An unyielding commitment to always putting patients first. Learn more about how we do this here
  • A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science
  • A place where you own the vision – both for your program and your own career path
  • A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
  • Access to learning and development resources to help you get in the best professional shape of your life
  • Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
  • Flexible PTO
  • Rapid career advancement for strong performers
  • Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time 
  • Partnerships with leading institutions
  • Commitment to Diversity, Equity & Inclusion
At BridgeBio, we strive to provide a market-competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health benefits. Below is the anticipated salary range for candidates for this role who will work in California. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, educational background, location of residence and performance during the interview process. BridgeBio is a multi-state employer, and this salary range may not reflect positions based in other states.
$205,000$245,000 USD


Director, Program Management

Calcilytix San Francisco, CA/Hybrid Program Management

Apply Now