Director of Pharmacology

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BridgeBio finds, develops, and delivers breakthrough medicines for genetic diseases. The company bridges remarkable advancements in genetic science with the entrepreneurial engine required to rapidly create lifesaving medicines for patients with unmet needs. Founded in 2015 by a team of industry veterans, the company has built a portfolio of 20 transformative drugs ranging from pre-clinical to late-stage development in multiple therapeutic areas, including genetic dermatology, oncology, cardiology, neurology, endocrinology, renal disease, and ophthalmology. The company’s focus on scientific excellence and rapid execution aim to translate today’s discoveries into tomorrow’s medicines. We have offices in San Francisco, Palo Alto, Boston, New York, and Raleigh with small satellites in other parts of the country. 

To learn more, visit us at https://bridgebio.com

Location

San Carlos, CA

Who You Are

This exciting opportunity is for a highly motivated and independent thinker to join a growing group of investigators developing novel small molecule therapeutics in Oncology.

The successful candidate will be a results-driven scientist with extensive experience in vivo pharmacology and a keen understanding of the drug discovery process. They will work in partnership with experienced drug hunters, external CROs, and academic collaborators to deliver IND-ready candidates for clinical testing. We are looking for a talented and enthusiastic individual who thrives in a collaborative, fast-paced, and growing environment.

Responsibilities

  • Lead in vivo Pharmacology efforts for BridgeBio Oncology programs:  target validation, IND-enabling studies, and clinical development/publications support
  • Design and execute in vivo pharmacology studies to support molecule advancement
  • Build PK/PD/Efficacy relationships
  • Propose and formulate a hypothesis for novel applications of selected candidate molecules
  • Manage interactions with team leaders to support molecule advancement
  • Develop, implement, and deliver on team collaborations: including initial proposal development, planning timelines and resources, monitoring milestones and final deliverables
  • Manage CROs to deliver high-quality data in a timely manner
  • Collaborate with academic researchers to develop and test mechanistic hypotheses
  • Work with KOLs to understand unmet clinical needs

Education, Experience & Skills Requirements

  • Ph.D., or MD/Ph.D. degree in any area of biological science, with experience in Oncology drug development and translational sciences
  • Accomplished Scientist as evidence by publication record with at least 8 years of drug development experience in an industry setting
  • Experience managing diverse and multiple CROs
  • Experience managing Scientist and Research Associate level personnel
  • Small molecule experience in the xenograft, syngeneic, and PDX models
  • Knowledge of cell signaling pathways as well as immunoncology
  • Experience writing pharmacology section of IND a plus
  • Strong communication skills (verbal and written) and presentation skills
  • Experience engaging with KOLs to deliver data
  • Passionate about finding ways to cure rare diseases
  • Ability to work in a small company with a largely virtual environment
  • Ability to manage complexity and uncertainty
  • Strong team interaction and communication skills
  • Embraces the BridgeBio core values:  1. Put patients first; 2. Think independently; 3. Be radically transparent; 4. Every minute counts; and 5. Let science speak

What We Offer

  • Patient Days, where we are fortunate enough to learn more about the lives we are looking to impact and a real exchange of ideas as to how we can improve our efforts
  • A culture inspired by our values: put patients first; think independently, be radically transparent; every minute counts, and let the science speak
  • Learning and development training to help employees be the best version of themselves
  • Collaborative business environment
  • Excellent compensation package (Base, Performance Bonus, Stock, RSU programs)
  • Excellent benefits package
  • Flexible PTO
  • With office locations in San Francisco, Boston, New York, and Raleigh, there are ample cross-collaboration opportunities with other BridgeBio Pharma programs
  • A fast-paced, data-driven, work environment with world-class R&D minds and capabilities
  • Work with the most productive groups of R&D operators in the industry
  • Partnerships with leading institutions
  • A platform for meaningful scientific contributions to shine
  • Commitment to Diversity & Inclusion – with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels respected for who they are, empowered to contribute, inspired to lead, and supported in their efforts to do so
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Director of Pharmacology

Apply Now