Director, DMPK

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BridgeBio finds, develops, and delivers breakthrough medicines for genetic diseases. The company bridges remarkable advancements in genetic science with the entrepreneurial engine required to rapidly create lifesaving medicines for patients with unmet needs. Founded in 2015 by a team of industry veterans, the company has built a portfolio of 20 transformative drugs ranging from pre-clinical to late-stage development in multiple therapeutic areas, including genetic dermatology, oncology, cardiology, neurology, endocrinology, renal disease, and ophthalmology. The company’s focus on scientific excellence and rapid execution aim to translate today’s discoveries into tomorrow’s medicines. We have offices in San Francisco, Palo Alto, Boston, New York, and Raleigh with small satellites in other parts of the country.

To learn more, visit us at https://bridgebio.com

Location

Remote

Who You Are

This is an exciting opportunity for a highly motivated and independent thinker to join a group of investigators developing novel small molecule cancer therapeutics. This successful candidate will be a results-driven scientist with a keen understanding of the drug discovery process. This individual will lead DMPK efforts as part of a group of cancer biologists charged with target validation and enabling optimization/selection of development candidates for our current lead, and new, oncology research programs. We are looking for a talented and enthusiastic individual who thrives in a collaborative, fast-paced, and growing environment

Responsibilities

  • Serve as the DMPK subject matter expert for nonclinical development
  • Prepare strategic and scientifically sophisticated DMPK drug development strategies that meet regulatory requirements and program goals
  • Manage CROs in the conduct of in vitro/in vivo ADME and DMPK modeling studies
  • Communicate DMPK results leading to key go, no-go decisions
  • Write, review, and edit preclinical DMPK reports of regulatory submissions

Education, Experience & Skills Requirements

  • Ph.D. in Pharmacokinetics, Pharmacology, Pharmaceutics, or other relevant fields with 7-10 years of experience in the biopharmaceutical industry, with evidence of drug development experience; Experience in oncology a plus
  • Strong knowledge of ADME concepts, pharmacokinetic modeling, pharmacodynamic, and bioanalytical principles.
  • Proficient in standard MS Software (Word, Excel, and PowerPoint)
  • Experience using WinNonlin or other pharmacokinetic software
  • Strong communication skills (verbal and written) and presentation skills required
  • Excellent interpersonal skills and the ability to represent DMPK in a team environment are essential

What We Offer

  • Patient Days, where we are fortunate enough to learn more about the lives we are looking to impact and a real exchange of ideas as to how we can improve our efforts
  • A culture inspired by our values: put patients first; think independently, be radically transparent; every minute counts, and let the science speak
  • Learning and development training to help employees be the best version of themselves
  • Collaborative business environment
  • Excellent compensation package (Base, Performance Bonus, Stock, RSU programs)
  • Excellent benefits package
  • Flexible PTO
  • With office locations in San Francisco, Boston, New York, and Raleigh, there are ample cross-collaboration opportunities with other BridgeBio Pharma programs
  • A fast-paced, data-driven, work environment with world-class R&D minds and capabilities
  • Work with the most productive groups of R&D operators in the industry
  • Partnerships with leading institutions
  • A platform for meaningful scientific contributions to shine
  • Commitment to Diversity & Inclusion – with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels respected for who they are, empowered to contribute, inspired to lead, and supported in their efforts to do so

careers

Director, DMPK

Apply Now