Associate Scientist II – Downstream Process Development

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BridgeBio ultimately exists to help patients. Millions worldwide are afflicted with genetic diseases, but small patient populations and industry reluctance to conduct early-stage development means that for many, treatments have not been forthcoming. We are committed to bridging this gap: between the business case and scientific possibility, between patient and hope.

To learn more, visit us at


Raleigh, NC


  • Perform experiments to support the development, optimization, and characterization of phase-appropriate downstream processes for the manufacture of AAV-based gene therapy drug candidates
  • Formulation of buffers and preparation/storage of equipment (e.g., TFF membranes, KrosFlo KR2is, pH/conductivity meters, chromatography columns, AKTAs) in support of the above
  • Assist in authoring protocols, process descriptions, and development reports
  • Work with Analytical Development to ensure relevant analytics are available to make data-driven development decisions
  • Present results to colleagues during Process Development and CMC meetings
  • Help develop work plans to make sure timelines are met
  • Support technical transfer and scale-up of processes for manufacturing campaigns at CDMO
  • Accountably document, organize, and provide 2nd scientist data verification of all experimental procedures, their execution, and data generated
  • Assist in the maintenance of laboratory equipment

Education, Experience & Skills Requirements

  • BS in Biology; Chemistry; Biochemistry; Mechanical, Chemical or Bioengineering; or related discipline
  • Minimum of 2 years of experience within the biopharmaceutical industry
  • Familiarity with GDP and electronic laboratory notebook (ELN)
  • Practical knowledge of several of the following skills/techniques:
    • Unicorn method writing/editing and operation of AKTA liquid chromatography systems to purify biomolecules via IEX, HIC, mixed-mode, or affinity chromatography
    • Tangential flow filtration (TFF) and sterile filtration
    • Buffer/solution preparation
    • Viral clearance
  • The qualified candidate must be a team player, able to think outside-the-box, and have a passion/sense of urgency for developing new therapies for patients with unmet needs.
  • Level commensurate with experience
  • Local Raleigh/Durham/Triangle, NC candidates are preferred

What We Offer

  • Patient Days, where we are fortunate enough to learn more about the lives we are looking to impact and a real exchange of ideas as to how we can improve our efforts
  • A culture inspired by our values: put patients first; think independently, be radically transparent; every minute counts, and let the science speak
  • Learning and development training to help employees be the best version of themselves
  • Collaborative business environment
  • Excellent compensation package (Base, Performance Bonus, Stock, RSU programs)
  • Excellent benefits package
  • Flexible PTO
  • With office locations in San Francisco, Boston, New York, and Raleigh, there are ample cross-collaboration opportunities with other BridgeBio Pharma programs
  • A fast-paced, data-driven, work environment with world-class R&D minds and capabilities
  • Work with the most productive groups of R&D operators in the industry
  • Partnerships with leading institutions
  • A platform for meaningful scientific contributions to shine
  • Commitment to Diversity & Inclusion – with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels respected for who they are, empowered to contribute, inspired to lead, and supported in their efforts to do so

Associate Scientist II – Downstream Process Development

Apply Now