Associate Scientist/Scientist, Pharmacology

Full-TimeBridgeBio OncologySouth San Francisco, CAPreclinical Research

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BridgeBio finds, develops, and delivers breakthrough medicines for genetic diseases. The company bridges remarkable advancements in genetic science with the entrepreneurial engine required to rapidly create lifesaving medicines for patients with unmet needs. Founded in 2015 by a team of industry veterans, the company has built a portfolio of 20 transformative drugs ranging from pre-clinical to late-stage development in multiple therapeutic areas including genetic dermatology, oncology, cardiology, neurology, endocrinology, renal disease, and ophthalmology. The company’s focus on scientific excellence and rapid execution aims to translate today’s discoveries into tomorrow’s medicines. We have offices in San Francisco, Palo Alto, Boston, New York, and Raleigh, with small satellites in other parts of the country. 

To learn more, visit us at https://bridgebio.com

Who You Are:

The Oncology Therapeutics team is hiring an exceptional and motivated Associate Scientist/Scientist to contribute to collaborative teams focused on the discovery and development of novel targeted small molecule oncology therapeutics.  The successful candidate will collaborate with team members to conduct in vivo pharmacology oncology research studies.  We are looking for a talented and enthusiastic individual who thrives in a collaborative, fast-paced, and growing environment to join our team. 
Responsibilities:
  • Design, plan, and execute in vivo (model development, tolerability, PK/PD, and efficacy) and ex vivo (target and mechanism engagement) pharmacology studies to assess the inhibition or activation of oncology targets with novel small molecule therapeutics 
  • Graph, analyze, and interpret experimental results 
  • Develop and deliver scientific presentations and reports in an efficient manner 
  • Provide strategic and technical leadership to junior pharmacology team members 
  • Manage studies at CROs 
  • Understand and implement applicable regulations around animal care/safety/handling 
Education, Experience & Skills Requirements:
  • A highly motivated, committed individual with good organizational skills and a demonstrated commitment to quality, attention to detail, and team player mentality 
  • A degree in a biology-related discipline 
  • Minimum BS and 8 years, MS and 6 years, or Ph.D. and 3 years of post-doc or < 3 years of industry experience 
  • Hands-on experience in a vivarium in an oncology setting required 
  • Experience with oncology cell line-derived xenograft and syngeneic in vivo models: cell implantation, tumor measurements, dosing (e.g., IV, PO, SC, IP), and blood sampling 
  •  Experience with mammalian cell culture, test article formulation, protein expression quantification (ELISA, MSD, HTRF, FACS, westerns, IHC), and qPCR 
  • Industry experience is highly preferred 
  • Strong written and oral communication skills 
  • Embraces the BridgeBio core values:  1. put patients first; 2. think independently, 3. be radically transparent; 4. every minute counts; and 5. let science speak  
What We Offer:
  • Patient Days, where we are fortunate enough to learn more about the lives we are looking to impact and a real exchange of ideas as to how we can improve our efforts
  • A culture inspired by our values: put patients first; think independently, be radically transparent; every minute counts, and let the science speak
  • Learning and development training to help employees be the best version of themselves
  • Collaborative business environment
  • Excellent compensation package (Base, Performance Bonus, Stock, RSU programs)
  • Excellent benefits package
  • Flexible PTO
  • With office locations in San Francisco, Boston, New York, and Raleigh, there are ample cross-collaboration opportunities with other BridgeBio Pharma programs
  • A fast-paced, data-driven, work environment with world-class R&D minds and capabilities
  • Work with the most productive groups of R&D operators in the industry
  • Partnerships with leading institutions
  • A platform for meaningful scientific contributions to shine
  • Commitment to Diversity & Inclusion – with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels respected for who they are, empowered to contribute, inspired to lead, and supported in their efforts to do so
We will not accept unsolicited resumes from agencies. Please do not send agency resumes to our website or BridgeBio and affiliating employees.
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Associate Scientist/Scientist, Pharmacology

Full-TimeBridgeBio OncologySouth San Francisco, CAPreclinical Research

Apply Now