Statistical Geneticist

Full-TimeBridgeBioAny Office LocationBiostatistics & Data Management

Apply Now

BridgeBio finds, develops, and delivers breakthrough medicines for genetic diseases. The company bridges remarkable advancements in genetic science with the entrepreneurial engine required to rapidly create lifesaving medicines for patients with unmet needs. Founded in 2015 by a team of industry veterans, the company has built a portfolio of 20 transformative drugs ranging from pre-clinical to late-stage development in multiple therapeutic areas including genetic dermatology, oncology, cardiology, neurology, endocrinology, renal disease, and ophthalmology. The company’s focus on scientific excellence and rapid execution aims to translate today’s discoveries into tomorrow’s medicines. We have offices in San Francisco, Palo Alto, Boston, New York, and Raleigh, with small satellites in other parts of the country. 

To learn more, visit us at https://bridgebio.com

Who You Are:

We are looking for an ambitious, versatile Statistical Geneticist to join our Computational Genetics Team at BridgeBio. The candidate would have frequent opportunities to interact with final decision-makers, diverse teams within BridgeBio, and external collaborators. This position’s primary function is threefold: analyze human genetic data to quantify statistical support for drug targets, provide bioinformatics/statistical genetics analyses to ongoing programs within BridgeBio, and identify novel targets by integrating multiple human genetic evidence. A chance to directly impact creating new drug development programs and support our current pipeline of various Mendelian and targeted cancer therapies.
Responsibilities:
  • Use a broad array of available datasets to interpret human genetic associations to disease and map genetic variants to target genes to validate drug targets and identify novel ones
  • Design and conduct innovative analyses to support or oppose mechanisms proposed by specific treatment
  • Stay up to date on state-of-the-art statistical genetics and bioinformatics literature
  • Develop inventive approaches to mine novel insights from both Mendelian and complex human genetics, including (but not limited to) the expansion of indication, resolving mechanism of action, patient stratification, biomarker identification, and disease progression or response prediction
  • Identify and acquire other data assets and improve the accessibility of this information by building tools to query the data along with existing datasets interactively
  • Communicate results and analyses clearly to both technical and non-technical audiences
  • Collaborate with investment and operating personnel throughout the BridgeBio portfolio
Education, Experience & Skills Requirements:
  • Ph.D. in statistical genetics, human genetics or similar field and 1+ years working experience, or bachelors/masters in quantitative or biological science plus 3-5+ years of relevant experience
  • Experience with genotype-phenotype association studies (GWAS, PheWAS, etc.) in the context of large biobanks (ex. UK Biobank)
  • Direct working experience with genetic datasets of >100,000 individuals in genotyping array, WES, or WGS.
  • Experience in variant annotation, linking variant to gene, and identifying associated cell type/tissue
  • Understanding of functional genomics datasets and their use in elucidating the mechanism of action
  • Knowledge in Mendelian randomization and polygenic risk scores
  • Understand the correct applications and limitations of large biobanks and association studies
  • Experience with working on large HPC systems or cloud environment
  • Experience with wet-lab biological experimentation is a plus but not required
  • Comfort working independently and in small teams
  • Curiosity and a desire to learn
What We Offer:
  • Patient Days, where we are fortunate enough to learn more about the lives we are looking to impact and a real exchange of ideas as to how we can improve our efforts
  • A culture inspired by our values: put patients first; think independently, be radically transparent; every minute counts, and let the science speak
  • Learning and development training to help employees be the best version of themselves
  • Collaborative business environment
  • Excellent compensation package (Base, Performance Bonus, Stock, RSU programs)
  • Excellent benefits package
  • Flexible PTO
  • With office locations in San Francisco, Boston, New York, and Raleigh, there are ample cross-collaboration opportunities with other BridgeBio Pharma programs
  • A fast-paced, data-driven, work environment with world-class R&D minds and capabilities
  • Work with the most productive groups of R&D operators in the industry
  • Partnerships with leading institutions
  • A platform for meaningful scientific contributions to shine
  • Commitment to Diversity & Inclusion – with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels respected for who they are, empowered to contribute, inspired to lead, and supported in their efforts to do so
We will not accept unsolicited resumes from agencies. Please do not send agency resumes to our website or BridgeBio and affiliating employees.
careers

Statistical Geneticist

Full-TimeBridgeBioAny Office LocationBiostatistics & Data Management

Apply Now