Statistical Geneticist

Full-TimeBridgeBioAny Office LocationBiostatistics & Data Management

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About BridgeBio

BridgeBio is a biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company has built a portfolio of 30+ drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs.

Our focus on scientific excellence and rapid execution aim to translate today’s discoveries into tomorrow’s medicines. We have U.S. offices in San Francisco, Palo Alto, Boston, New York, and Raleigh, with small satellites in other parts of the country. We also have international offices in Montreal, Canada, and Zug, Switzerland, and are expanding across Europe.

To learn more about our story and company culture, visit us at https://bridgebio.com

Who You Are:

We are looking for an ambitious, versatile Statistical Geneticist to join our Computational Genetics Team at BridgeBio. The candidate would have frequent opportunities to interact with final decision-makers, diverse teams within BridgeBio, and external collaborators. This position’s primary function is threefold: analyze human genetic data to quantify statistical support for drug targets, provide bioinformatics/statistical genetics analyses to ongoing programs within BridgeBio, and identify novel targets by integrating multiple human genetic evidence. A chance to directly impact creating new drug development programs and support our current pipeline of various Mendelian and targeted cancer therapies.
Responsibilities:
  • Use a broad array of available datasets to interpret human genetic associations to disease and map genetic variants to target genes to validate drug targets and identify novel ones
  • Design and conduct innovative analyses to support or oppose mechanisms proposed by specific treatment
  • Stay up to date on state-of-the-art statistical genetics and bioinformatics literature
  • Develop inventive approaches to mine novel insights from both Mendelian and complex human genetics, including (but not limited to) the expansion of indication, resolving mechanism of action, patient stratification, biomarker identification, and disease progression or response prediction
  • Identify and acquire other data assets and improve the accessibility of this information by building tools to query the data along with existing datasets interactively
  • Communicate results and analyses clearly to both technical and non-technical audiences
  • Collaborate with investment and operating personnel throughout the BridgeBio portfolio

  • No matter your role at BridgeBio, successful team members are:
  • Patient Champions, who put patients first and uphold strict ethical standards
  • Entrepreneurial Operators, who drive towards practical solutions and have an ownership mindset
  • Truth Seekers, who are detailed, rational, and humble problem solvers
  • Individuals Who Inspire Excellence in themselves and those around them
  • High-quality executors, who execute against goals and milestones with quality, precision, and speed
Education, Experience & Skills Requirements:
  • Ph.D. in statistical genetics, human genetics or similar field and 1+ years working experience, or bachelors/masters in quantitative or biological science plus 3-5+ years of relevant experience
  • Experience with genotype-phenotype association studies (GWAS, PheWAS, etc.) in the context of large biobanks (ex. UK Biobank)
  • Direct working experience with genetic datasets of >100,000 individuals in genotyping array, WES, or WGS.
  • Experience in variant annotation, linking variant to gene, and identifying associated cell type/tissue
  • Understanding of functional genomics datasets and their use in elucidating the mechanism of action
  • Knowledge in Mendelian randomization and polygenic risk scores
  • Understand the correct applications and limitations of large biobanks and association studies
  • Experience with working on large HPC systems or cloud environment
  • Experience with wet-lab biological experimentation is a plus but not required
  • Comfort working independently and in small teams
  • Curiosity and a desire to learn
What We Offer:
  • Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
  • A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
  • An unyielding commitment to always putting patients first. Learn more about how we do this here
  • A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science
  • A place where you own the vision – both for your program and your own career path
  • A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
  • Access to learning and development resources to help you get in the best professional shape of your life
  • Robust and market competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
  • Flexible PTO
  • Rapid career advancement for strong performers
  • Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time
  • Partnerships with leading institutions
  • Commitment to Diversity, Equity & Inclusion – with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels seen, valued, and heard
We will not accept unsolicited resumes from agencies. Please do not send agency resumes to our website or BridgeBio and affiliating employees.
careers

Statistical Geneticist

Full-TimeBridgeBioAny Office LocationBiostatistics & Data Management

Apply Now